Journal article
Peroxisome Proliferator-activated Receptors and Retinoid X Receptor-alpha in Term Human Gestational Tissues: Tissue Specific and Labour-associated Changes
SJ Holdsworth-Carson, M Permezel, C Riley, GE Rice, M Lappas
Placenta | W B SAUNDERS CO LTD | Published : 2009
Abstract
Peroxisome proliferator-activated receptors (PPARs) and their transcriptional partner retinoid X receptor (RXR) are involved in transcriptionally regulating the events that contribute to the control of parturition in humans. Definitive data, however, are lacking with respect to PPAR and RXR expression and activation during term labour in human gestational tissues. The aim of this study, therefore, was to identify tissue and labour-associated changes of PPAR isoforms (α, δ and γ) and RXRα in placenta, amnion and choriodecidua. Gestational tissues from term non-labouring women were used for immunohistochemistry localisation and confirmation studies of PPAR isoforms (α, δ and γ) and RXRα. Human..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
Dr Martha Lappas was a recipient of a National Health and Medical Research Council RD Wright Fellowship (grant no. 454777). The work described in this manuscript was funded by the NHMRC (project grant no. 367615). We would like to thank the Medical Research Foundation for Women and Babies for providing funding for the Spectrophotometer and the MinoOption 2-colour Real-time PCR system. We would like to gratefully acknowledge Michelle Colorniere (from the Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women) for her assistance with RT-PCR calculations and clinical research midwifes Valerie Bryant, Gabrielle De Bruyn and Anne Beeston, and the obstetric and midwifery staff of the Mercy Hospital for Women for their co-operation.